A phase 1 ‘window-of-opportunity’ trial testing evofosfamide (TH-302), a tumour-selective hypoxia-activated cytotoxic prodrug, with preoperative chemoradiotherapy in oesophageal adenocarcinoma patients
Neo-adjuvant chemoradiotherapy followed by surgery is the standard treatment with curative intent for oesophageal cancer patients, with...
Improved high-dimensional prediction with Random Forests by the use of co-data
Prediction in high dimensional settings is difficult due to the large number of variables relative to the sample size. We demonstrate...
Radiomic analysis of soft tissues sarcomas can distinguish intermediate from high-grade lesions
MRI (echo planar SE, 1.5T) from 19 patients with STSs and a known histological grading, were retrospectively analyzed. The apparent diffusion coefficient (ADC)...
Are Fusion Transcripts in Relapsed/Metastatic Head and Neck Cancer Patients Predictive of Response to Anti-EGFR Therapies?
Prediction of benefit from combined chemotherapy and the antiepidermal growth factor receptor cetuximab is a not yet solved question in head and neck squamous cell...
Predictive and prognostic value of CT based radiomics signature in locally advanced head and neck cancers patients treated with concurrent chemoradiotherapy or bioradiotherapy and its added value to Human Papillomavirus status
The analysis presented in the paper suggests an added value of radiomics features as prognostic and predictive biomarker in HNSCC treated with CRT/BRT. Moreover,...
Feature selection methodology for longitudinal cone-beam CT radiomics
This paper describes a feature selection methodology for longitudinal radiomics that is able to select reproducible delta radiomics features that are informative...
Moving towards Personalized Therapy in Head and Neck Squamous Cell Carcinoma through Analysis of Next Generation Sequencing Data
Personalized medicine tumor boards, which leverage genomic data to improve clinical management, are becoming standard for the treatment of many cancers. This paper...
Radiomics: the bridge between medical imaging and personalized medicine
Radiomics, the high-throughput mining of quantitative image features from standard-of-care medical imaging that enables data to be extracted and applied within...
Definition of a Decision Support System to Support Research on Head and Neck Cancer
The work of a researcher in the field of medicine, and concretely in cancer, involves consulting and...Jeju Island, Korea
Gene Expression Signatures for Head and Neck Cancer Patient Stratification: Are Results Ready for Clinical Application?
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer by incidence worldwide and considering the recent EUROCARE-5 population-based...
Towards a validated Decision Aid Tool for advanced larynx cancer patients
Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach
Biomarkers predicting treatment response to the monoclonal antibody cetuximab in locally advanced head and neck squamous cell carcinomas (LAHNSCC) are lacking. We...
Radiomics in Head and Neck Cancer: Extracting Valuable Information from Data beyond Recognition
In oncology, biomarkers that describe the...